Endocrine Abstracts

Background: Changes of the gut microbiota may impact on the mechanisms of immune tolerance in Graves’ disease (GD) and Graves’ orbitopathy (GO). Probiotics, which contain live micro-organisms, can modify the composition of the gut microbiota.Aims: We tested in a double-blind randomized placebo controlled trial whether the administration of a well-characterized, commercially available, probiotic would 1) modify the microbiota composition in GD/G...

As known, an imbalance of the gut microbiota is associated with a higher risk for autoimmune diseases. Moreover the increased rates of autoimmunity reported in urban residential areas worldwide suggest a possible influence of diet. We report on the antibody response to food antigens in GD patients. Since 10% of celiac patients develop an autoimmune thyreopathy we focused on gliadin (DGP), transglutaminases (tTG) and 40 other food antigens (FA). Commercially available ELISA ass...

Graves’ Disease (GD) affects about 2% of the population in the UK, with female predominance. A proportion of GD patients (5–50%) develop orbitopathy (GO), which is characterized by tissue remodeling in the orbit leading to protrusion of the eye (proptosis). Blood biomarkers associated with GD or GO could be useful diagnostic or prognostic tools for researchers and clinicians. Within the framework of INDIGO IAPP-612116 (Investigation of Novel biomarkers and Definition...